Ashwagandha has been an important herb in the Ayurvedic and indigenous medical systems for over 3000 years. Historically, the plant has been used as an aphrodisiac, liver tonic, anti- inflammatory agent, insomnia and senile dementia. Clinical trials and animal research support the use of ashwagandha for anxiety, cognitive neurological disorders, inflammation, and Parkinson's disease. Ashwagandha is also used therapeutically as an adaptogen for patients with nervous exhaustion, insomnia, and debility due to stress and as an immune stimulant.
In ashwagandha withanolides serve as important hormone precursors that can convert into human physiologic hormones as needed. Ashwagandha is thought to be amphoteric; i.e., it can help regulate important physiologic processes.
Ashwagandha is also considered to be an anti-stress adaptogen, facilitating the ability to withstand stressors and has antioxidant properties as well. Chronic stress (CS) can result in a number of adverse physiologic conditions including cognitive deficit, immunosuppression, sexual dysfunction, gastric ulceration, irregularities in glucose homeostasis and changes in plasma corticosterone levels. In a study of chronic stress Ashwagandha extract was able to decrease the number and severity of CS-induced ulcers, reverse CS-induced inhibition of male sexual behavior, and inhibit the adverse effects of CS on retention of learned tasks and also reversed CS- induced immunosuppression.
Brahmi has been used in the Ayurvedic system of medicine for centuries. Traditionally, it was used as a brain tonic to enhance memory development, learning, concentration and to provide relief to patients with anxiety or epileptic disorders. Recent research has focused primarily on Brahmi's cognitive-enhancing effects specifically memory, learning, concentration and results support the traditional Ayurvedic claims. Research on anxiety, epilepsy, bronchitis and gastric ulcers also supports the Ayurvedic uses of Brahmi and its antioxidant properties may offer protection from free radical damage. Since Brahmi's primary therapeutic use is to enhance cognitive function, most research has focused on the mechanism behind these properties. The triterpenoid saponins and their bacosides are responsible for its ability to enhance nerve impulse transmission. The bacosides aid in repair of damaged neurons by enhancing kinase activity, neuronal synthesis and restoration of synaptic activity and ultimately nerve impulse transmission.
Gotu kola is used in Ayurvedic medicine for the treatment of anxiety. It energizes brain cells and is known to be very useful in improving learning and memory.
Black pepper is a natural bioavailability enhancer helps to increase absorption of the ingredients. Alkaloid piperine present in black pepper helps to reduce mental stress.