Dianova (Berberine 500mg) is used in Diabetes mellitus by increasing the glucose uptake inside the cells, insulin sensitizing effect, incretin effects and by DDP4 inhibition.
Dianova (Berberine 500mg) is used in Diabetes mellitus by increasing the glucose uptake inside the cells, insulin sensitizing effect, incretin effects and by DDP4 inhibition .Berberine enhances glucose metabolism by stimulation of glycolysis, which is related to inhibition of glucose oxidation in mitochondria.Thus increasing AMP:ATP Ratio & promoting AMPK activation
Improving insulin action by activating AMP-activated protein kinase AMPK (Metabolic Master Switch)
Improves glucose metabolism through induction of Glycolysis
Promoting GLP-1 (Incretins) secretion and modulating its release
(Incretins) cause short-term increase in the amount of Insulin
Inhibition of DPP-4 ,similar to Sitagliptin
Dipeptidyl peptidase-4 (DPP-4) is the enzyme responsible for inactivation of Incretins
Fatty liver disease
Dosage and directions for use
1 capsule twice in a Day
Hypersensitivity to ingredient.
Store in a cool, dark & dry place keep out of reach of children.
Should be avoided in patients taking macrolide
antibiotics like azithromycin, clarithromycin
and Immunosuppressant, Cyclosporins
May cause gastric discomfort in sensitive individuals
in initial days of use which subsides gradually .